The G Protein–Biased κ-Opioid Receptor Agonist RB-64 Is Analgesic with a Unique Spectrum of Activities In Vivo

Psychotomimesis Mediated by κ Opiate Receptors

Andreas Pfeiffer, Victor Brantl, Albert Herz et al. · Science · 1986 · 858 citations

Medicine, Behavioral Sciences, Pharmacology +16

Automated design of ligands to polypharmacological profiles

Jérémy Besnard, G.F. Ruda, Vincent Setola et al. · Nature · 2012 · 845 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +14

Salvinorin A: A potent naturally occurring nonnitrogenous κ opioid selective agonist

Bryan L. Roth, Karen Baner, Richard B. Westkaemper et al. · Proceedings of the National Academy of Sciences · 2002 · 780 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11

A G Protein-Biased Ligand at the μ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphine

Scott M. DeWire, Dennis S. Yamashita, David H. Rominger et al. · Journal of Pharmacology and Experimental Therapeutics · 2013 · 655 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses.

Jay P. McLaughlin, Monica Marton-Popovici, Charles Chavkin · PubMed · 2003 · 480 citations · Full text

Medicine, Neuroscience, Pharmacology +17