A human monoclonal antibody 264RAD targeting αvβ6 integrin reduces tumour growth and metastasis, and modulates key biomarkers in vivo

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

John S. Munger, Xiaozhu Huang, Hisaaki Kawakatsu et al. · Cell · 1999 · 2.1K citations

Life Sciences, Cell Biology, Physiology +16

Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes

Yoko S. DeRose, Guoying Wang, Yi‐Chun Lin et al. · Nature Medicine · 2011 · 1K citations · Full text

Medicine, Cancer Biology, Oncology +17

The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1

Dezhi Mu, Stephanie Cambier, Lars Fjellbirkeland et al. · The Journal of Cell Biology · 2002 · 717 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia.

Lone Rønnov‐Jessen, Ole W. Petersen · PubMed · 1993 · 518 citations

Medicine, Cancer Biology, Oncology +15

Integrin αVβ6-mediated activation of latent TGF-β requires the latent TGF-β binding protein-1

Justin P. Annes, Yan Chen, John S. Munger et al. · The Journal of Cell Biology · 2004 · 490 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +10