Concepedia

Integrin Affinity Regulation

Integrin Affinity Regulation is a molecular mechanism within integrin signaling that governs the dynamic modulation of integrin receptor binding strength to extracellular matrix ligands through conformational changes in integrin structure.

416

Publications

33.5K

Citations

1.9K

Authors

559

Institutions

Publications per year

2017–2026

38

Parents

Publications

416

Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

Seiji Tadokoro, Sanford J. Shattil, Koji Eto et al. · Science · 2003 · 1.2K citations

, , +16

The Talin Head Domain Binds to Integrin β Subunit Cytoplasmic Tails and Regulates Integrin Activation

David Calderwood, Roy Zent, Richard P. Grant et al. · Journal of Biological Chemistry · 1999 · 719 citations · Full text

, , +17

Critical role for β7 integrins in formation of the gut-associated lymphoid tissue

Norbert Wagner, Jürgen Löhler, Eric J. Kunkel et al. · Nature · 1996 · 574 citations

, , +16

Structures of the αL I Domain and Its Complex with ICAM-1 Reveal a Shape-Shifting Pathway for Integrin Regulation

Motomu Shimaoka, Tsan Sam Xiao, Jin-huan Liu et al. · Cell · 2003 · 522 citations

, , +16

Chemokines Trigger Immediate β2 Integrin Affinity and Mobility Changes

Gabriela Constantin, Cinzia Giagulli, Laura Piccio et al. · Immunity · 2000 · 517 citations · Full text

, , +12

1–5 of 416

Authors

1.9K

  1. TA
    Timothy A. Springer

    Harvard University, United States

    37 publications · 4.2K citations

    31

    h-index

  2. MH
    Mark H. Ginsberg

    University of California San Diego, United States

    19 publications · 4.7K citations

    19

    h-index

  3. SJ
    Sanford J. Shattil

    Scripps Research Institute, United States

    11 publications · 2.8K citations

    11

    h-index

  4. MJ
    Martin J. Humphries

    University of Manchester, United Kingdom

    10 publications · 935 citations

    10

    h-index

  5. YT
    Yoshikazu Takada

    Scripps Research Institute, United States

    10 publications · 1.1K citations

    9

    h-index

1–5 of 1.9K

Institutions

559

  1. Harvard University

    Cambridge, United States

    35 h-index

    172 publications

    19.5K citations

  2. Scripps Research Institute

    San Diego, United States

    28 h-index

    99 publications

    25.7K citations

  3. Boston Children's Hospital

    Boston, United States

    20 h-index

    59 publications

    4.9K citations

  4. University of California San Diego

    San Diego, United States

    13 h-index

    48 publications

    3.7K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    13 h-index

    63 publications

    5.3K citations

  6. University of California, San Francisco

    San Francisco, United States

    11 h-index

    43 publications

    2.7K citations

  7. University of Pennsylvania

    Philadelphia, United States

    11 h-index

    25 publications

    2.6K citations

  8. Max Planck Institute of Biochemistry

    Martinsried, Germany

    11 h-index

    24 publications

    1.4K citations

1–8 of 559

Venues

  1. Journal of Biological Chemistry

    JBC · 84 publications · 7.7K citations

    52

    h-index

  2. Blood

    19 publications · 1.1K citations

    19

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 18 publications · 1.6K citations

    18

    h-index

  4. The Journal of Cell Biology

    JCB · 17 publications · 2.7K citations

    17

    h-index

  5. The Journal of Immunology

    JI · 16 publications · 899 citations

    15

    h-index

1–5