Tsan Sam Xiao

IFI16 is an innate immune sensor for intracellular DNA

Leonie Unterholzner, Sinéad E. Keating, Marcin Baran et al. · Nature Immunology · 2010 · 1.6K citations · Full text

Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics

Tsan Sam Xiao, Junichi Takagi, Barry S. Coller et al. · Nature · 2004 · 836 citations · Full text

Cell Adhesion, Molecular Biology, Cell-matrix Interaction +7

Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis

Joseph K. Rathkey, Junjie Zhao, Zhonghua Liu et al. · Science Immunology · 2018 · 561 citations · Full text

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

Tengchuan Jin, Andrew Perry, Jiansheng Jiang et al. · Immunity · 2012 · 547 citations · Full text

Aim2 Inflammasome, Signal Transduction, Receptor (Biochemistry) +9

Structures of the αL I Domain and Its Complex with ICAM-1 Reveal a Shape-Shifting Pathway for Integrin Regulation

Motomu Shimaoka, Tsan Sam Xiao, Jin-huan Liu et al. · Cell · 2003 · 519 citations

Molecular Physiology, Signal Transduction, Signaling Pathway +13