Concepedia

Integrin Affinity Modulation

Integrin Affinity Modulation is a molecular mechanism in cell adhesion biology that regulates the binding strength of integrin receptors on leukocytes to their ligands on endothelial cells through conformational changes, thereby controlling leukocyte trafficking during immune responses.

217

Publications

18.2K

Citations

1.1K

Authors

339

Institutions

Publications per year

2017–2026

21

Variants

Integrin Activation

Parents

Publications

217

Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

Seiji Tadokoro, Sanford J. Shattil, Koji Eto et al. · Science · 2003 · 1.2K citations

, , +16

The Talin Head Domain Binds to Integrin β Subunit Cytoplasmic Tails and Regulates Integrin Activation

David Calderwood, Roy Zent, Richard P. Grant et al. · Journal of Biological Chemistry · 1999 · 719 citations · Full text

, , +17

A Comprehensive Evaluation of the Activity and Selectivity Profile of Ligands for RGD-binding Integrins

Tobias G. Kapp, Florian Rechenmacher, Stefanie Neubauer et al. · Scientific Reports · 2017 · 611 citations · Full text

, , +16

Multivalent Effects of RGD Peptides Obtained by Nanoparticle Display

Xavier Montet, Martin Funovics, Karin Montet-Abou et al. · Journal of Medicinal Chemistry · 2006 · 384 citations

, , +17

Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity.

Anna Huttenlocher, Mark H. Ginsberg, Alan F. Horwitz · The Journal of Cell Biology · 1996 · 364 citations · Full text

, , +15

1–5 of 217

Authors

1.1K

  1. TA
    Timothy A. Springer

    Harvard University, United States

    16 publications · 1.4K citations

    16

    h-index

  2. MH
    Mark H. Ginsberg

    University of California San Diego, United States

    11 publications · 3.5K citations

    11

    h-index

  3. SJ
    Sanford J. Shattil

    Scripps Research Institute, United States

    10 publications · 2.7K citations

    10

    h-index

  4. AC
    Alexandre Chigaev

    University of New Mexico, United States

    7 publications · 425 citations

    7

    h-index

  5. LA
    Larry A. Sklar

    University of New Mexico, United States

    7 publications · 425 citations

    7

    h-index

1–5 of 1.1K

Institutions

339

  1. Harvard University

    Cambridge, United States

    25 h-index

    96 publications

    9.2K citations

  2. Scripps Research Institute

    San Diego, United States

    18 h-index

    66 publications

    20.3K citations

  3. Boston Children's Hospital

    Boston, United States

    11 h-index

    27 publications

    1.7K citations

  4. University of New Mexico

    Albuquerque, United States

    7 h-index

    29 publications

    1.6K citations

  5. New Mexico Cancer Center

    Albuquerque, United States

    7 h-index

    26 publications

    1.5K citations

  6. Weizmann Institute of Science

    Rehovot, Israel

    7 h-index

    32 publications

    5.2K citations

  7. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    6 h-index

    22 publications

    1.6K citations

  8. University of Pennsylvania

    Philadelphia, United States

    6 h-index

    17 publications

    1.3K citations

1–8 of 339

Venues

  1. Journal of Biological Chemistry

    JBC · 42 publications · 3.8K citations

    33

    h-index

  2. The Journal of Immunology

    JI · 14 publications · 1.2K citations

    14

    h-index

  3. Blood

    11 publications · 877 citations

    11

    h-index

  4. The Journal of Cell Biology

    JCB · 9 publications · 1.7K citations

    9

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 9 publications · 717 citations

    9

    h-index

1–5