Concepedia

Sequential aldol condensation catalyzed by DERA mutant Ser238Asp and a formal total synthesis of atorvastatin

Junjie Liu, Che‐Chang Hsu, Chi‐Huey Wong

Tetrahedron Letters · 2004 · 87 citations · 13 references

DOI

Concepts

References

13

Observation of Covalent Intermediates in an Enzyme Mechanism at Atomic Resolution

A. Heine, Grace DeSantis, J.G. Luz et al. · Science · 2001 · 279 citations

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Inhibitors of cholesterol biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran 2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus

Bruce D. Roth, C. John Blankley, Alexander Chucholowski et al. · Journal of Medicinal Chemistry · 1991 · 183 citations · Full text

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Unprecedented Asymmetric Aldol Reactions with Three Aldehyde Substrates Catalyzed by 2-Deoxyribose-5-phosphate Aldolase

Harrie J. M. Gijsen, Chi‐Huey Wong · Journal of the American Chemical Society · 1994 · 170 citations

, , +13

The convergent synthesis of CI-981, an optically active, highly potent, tissue selective inhibitor of HMG-CoA reductase

Kelvin L. Baumann, Donald E. Butler, Carl F. Deering et al. · Tetrahedron Letters · 1992 · 123 citations

, , +7

Structure-Based mutagenesis approaches toward expanding the substrate specificity of d-2-Deoxyribose-5-phosphate aldolase

Grace DeSantis, Junjie Liu, David P. Clark et al. · Bioorganic & Medicinal Chemistry · 2003 · 121 citations

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