Folic acid deficiency increases chromosomal instability, chromosome 21 aneuploidy and sensitivity to radiation-induced micronuclei

Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage

Benjamin C. Blount, M. M. Mack, Carol M. Wehr et al. · Proceedings of the National Academy of Sciences · 1997 · 1.4K citations

Life Sciences, Genetics, Molecular Biology +17

Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome

S J James, Marta Pogribna, Igor P. Pogribny et al. · American Journal of Clinical Nutrition · 1999 · 452 citations · Full text

Life Sciences, Genetics, Molecular Genetics +16

Micronuclei, nucleoplasmic bridges and nuclear buds induced in folic acid deficient human lymphocytes—evidence for breakage–fusion-bridge cycles in the cytokinesis-block micronucleus assay

Michael Fenech, Jimmy W. Crott · Mutation research. Fundamental and molecular mechanisms of mutagenesis · 2002 · 310 citations

Life Sciences, Cell Biology, Genetics +17

Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults

Michael Fenech · Carcinogenesis · 1998 · 310 citations · Full text

Public Health, Nutrition, Nutritional Sciences +15

DNA instability (strand breakage, uracil misincorporation, and defective repair) is increased by folic acid depletion in human lymphocytes <i>in vitro</i>

Susan J. Duthie, Azelle Hawdon · The FASEB Journal · 1998 · 290 citations

Life Sciences, Genetics, Molecular Biology +17