Concepedia

Apoptosis-based dual molecular targeting by INNO-406, a second-generation Bcr-Abl inhibitor, and ABT-737, an inhibitor of antiapoptotic Bcl-2 proteins, against Bcr-Abl-positive leukemia

Junya Kuroda, Shinya Kimura, Andreas Strasser, Michael Andreeff, Lorraine A. O’Reilly, Eishi Ashihara, Yuri Kamitsuji, Asumi Yokota, Eri Kawata, Miki Takeuchi,

Cell Death and Differentiation · 2007 · 65 citations · 35 references

DOI

Concepts

References

35

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

Tilman Oltersdorf, Steven W. Elmore, Alexander R. Shoemaker et al. · Nature · 2005 · 3.4K citations

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Overriding Imatinib Resistance with a Novel ABL Kinase Inhibitor

Neil P. Shah, Chris Tran, Francis Y. Lee et al. · Science · 2004 · 1.8K citations

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Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl

Ellen Weisberg, Paul W. Manley, Werner Breitenstein et al. · Cancer Cell · 2005 · 1.5K citations · Full text

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized

Mark F. van Delft, Andrew H. Wei, Kylie D. Mason et al. · Cancer Cell · 2006 · 1.2K citations · Full text

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Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells

Esther A. Obeng, Louise Carlson, Delia Gutman et al. · Blood · 2006 · 1.1K citations · Full text

, , +15