Leptin-dependent Phosphorylation of PTEN Mediates Actin Restructuring and Activation of ATP-sensitive K+ Channels

Abstract

Leptin activates multiple signaling pathways in cells, including the phosphatidylinositol 3-kinase pathway, indicating a degree of cross-talk with insulin signaling. The exact mechanisms by which leptin alters this signaling pathway and how it relates to functional outputs are unclear at present. A previous study has established that leptin inhibits the activity of the phosphatase PTEN (phosphatase and tensin homolog deleted on chromosome 10), an important tumor suppressor and modifier of phosphoinositide signaling. this study that leptin multiple on the of PTEN in and an by of the and PTEN PTEN the in of the leptin to and and activity by insulin leptin in in this of leptin in a PTEN in leptin and a important signaling to outputs Leptin activates multiple signaling pathways in cells, including the phosphatidylinositol 3-kinase pathway, indicating a degree of cross-talk with insulin signaling. The exact mechanisms by which leptin alters this signaling pathway and how it relates to functional outputs are unclear at present. A previous study has established that leptin inhibits the activity of the phosphatase PTEN (phosphatase and tensin homolog deleted on chromosome 10), an important tumor suppressor and modifier of phosphoinositide signaling. this study that leptin multiple on the of PTEN in and an by of the and PTEN PTEN the in of the leptin to and and activity by insulin leptin in in this of leptin in a PTEN in leptin and a important signaling to outputs signaling by leptin and insulin the of with in with and at has a in the signaling with the of insulin on a of of leptin signaling with indicating that leptin and insulin signaling in to signaling the and of and phosphatidylinositol pathways in leptin and insulin leptin and insulin and on the in leptin and insulin leptin the signaling pathways the exact of the signaling and with and with it that in cells, the the by leptin that of insulin leptin on leptin the and which in in the of leptin signaling to in and in and in and of by leptin on in The and to to of PTEN and phosphatase activity PTEN this study on the mechanisms by which leptin alters PTEN in and The activity of PTEN to on at and in the PTEN with PTEN in an The of are and with at a of and to of the on PTEN and and that PTEN and to signaling of with insulin that leptin of PTEN phosphatase activity and PTEN at the to of the PTEN at has to PTEN at and in in a of PTEN phosphatase activity has to PTEN at and in cells, with the activity of leptin of PTEN at and in a and and the of and to and and and with and and in and with and and in a of and and by the to the and by and and in at of and of PTEN with of at to the and with of The to the cells, at with and and PTEN and a of cells, by PTEN with to in and leptin with with in and with leptin in the of in in with and with a PTEN The in with a and by of and to of of and of a of and cells, in to with in the and of the and PTEN and and and and and at and and at and and at on by with to and and of with to of at on a The and with of and 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