Sheelagh Frame

GSK3 takes centre stage more than 20 years after its discovery

Sheelagh Frame, Philip Cohen · Biochemical Journal · 2001 · 978 citations

Life Sciences, Biochemistry, Molecular Biology +17

A Common Phosphate Binding Site Explains the Unique Substrate Specificity of GSK3 and Its Inactivation by Phosphorylation

Sheelagh Frame, Philip Cohen, Ricardo M. Biondi · Molecular Cell · 2001 · 702 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +10

Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event

Adam R. Cole, Sheelagh Frame, Philip Cohen · Biochemical Journal · 2004 · 321 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Seliciclib (CYC202, R-Roscovitine) Induces Cell Death in Multiple Myeloma Cells by Inhibition of RNA Polymerase II–Dependent Transcription and Down-regulation of Mcl-1

David E. MacCallum, Jean Melville, Sheelagh Frame et al. · Cancer Research · 2005 · 286 citations · Full text

Medicine, Oncology, Pharmacology +17

A GSK3‐binding peptide from FRAT1 selectively inhibits the GSK3‐catalysed phosphorylation of Axin and β‐catenin

Gareth M. Thomas, Sheelagh Frame, Michel Goedert et al. · FEBS Letters · 1999 · 230 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15