Sheelagh Frame

GSK3 takes centre stage more than 20 years after its discovery

Sheelagh Frame, Philip Cohen · Biochemical Journal · 2001 · 973 citations

Molecular Regulation, Cell Death, Cytoskeleton +18

A Common Phosphate Binding Site Explains the Unique Substrate Specificity of GSK3 and Its Inactivation by Phosphorylation

Sheelagh Frame, Philip Cohen, Ricardo M. Biondi · Molecular Cell · 2001 · 696 citations · Full text

Protein Function, Signal Transduction, Signaling Pathway +11

Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event

Adam R. Cole, Sheelagh Frame, Philip Cohen · Biochemical Journal · 2004 · 318 citations · Full text

Seliciclib (CYC202, R-Roscovitine) Induces Cell Death in Multiple Myeloma Cells by Inhibition of RNA Polymerase II–Dependent Transcription and Down-regulation of Mcl-1

David E. MacCallum, Jean Melville, Sheelagh Frame et al. · Cancer Research · 2005 · 284 citations · Full text

Apoptosis, Cell Death, Cell Cycle +16

A GSK3‐binding peptide from FRAT1 selectively inhibits the GSK3‐catalysed phosphorylation of Axin and β‐catenin

Gareth M. Thomas, Sheelagh Frame, Michel Goedert et al. · FEBS Letters · 1999 · 229 citations · Full text