The Hsp90-specific inhibitor, geldanamycin, blocks CD28-mediated activation of human T lymphocytes

Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

C. Erec Stebbins, Alicia A. Russo, Christine Schneider et al. · Cell · 1997 · 1.4K citations · Full text

Life Sciences, Biochemistry, Oncology +17

Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone

Chrisostomos Prodromou, S. Mark Roe, Ronan O’Brien et al. · Cell · 1997 · 1.3K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

JNK is involved in signal integration during costimulation of T lymphocytes

Bing Su, Estela Jacinto, Masahiko Hibi et al. · Cell · 1994 · 921 citations

Life Sciences, Cell Biology, Immunology +14

Phenotypic Change from Transformed to Normal Induced by Benzoquinonoid Ansamycins Accompanies Inactivation of p60 <i> ^src </i> in Rat Kidney Cells Infected with Rous Sarcoma Virus

Yoshimasa Uehara, Makoto Hori, TOMIO TAKEUCHI et al. · Molecular and Cellular Biology · 1986 · 218 citations

Life Sciences, Cell Biology, Pharmacology +7

The hsp90-binding Antibiotic Geldanamycin Decreases Raf Levels and Epidermal Growth Factor Signaling without Disrupting Formation of Signaling Complexes or Reducing the Specific Enzymatic Activity of Raf Kinase

Louis F. Stancato, Adam M. Silverstein, Janet Owens‐Grillo et al. · Journal of Biological Chemistry · 1997 · 201 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +13