Synthesis and optimization of an original V-shaped collection of 4-7-disubstituted Pyrido[3,2-d]pyrimidines as CDK5 and DYRK1A inhibitors

Structural Characterization of the GSK-3β Active Site Using Selective and Non-selective ATP-mimetic Inhibitors

J. A. Bertrand, Sandrine Thieffine, Anna Vulpetti et al. · Journal of Molecular Biology · 2003 · 314 citations

Life Sciences, Biochemistry, Medicinal Chemistry +12

Mechanism of CDK5/p25 Binding by CDK Inhibitors

Marina Mapelli, Lucia Massimiliano, Claudia Crovace et al. · Journal of Medicinal Chemistry · 2005 · 206 citations · Full text

Life Sciences, Neuroscience, Pharmacology +12

Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B

Tania Tahtouh, Jonathan M. Elkins, P. Filippakopoulos et al. · Journal of Medicinal Chemistry · 2012 · 188 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition

M. Soundararajan, A.K. Roos, P. Savitsky et al. · Structure · 2013 · 161 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Protein Kinases, Their Function and Implication in Cancer and Other Diseases

Igor Shchemelinin, Luděk Šefc, E Nečas · Folia Biologica · 2006 · 141 citations · Full text

Medicine, Cancer Biology, Oncology +10