PD-L1 is induced in hepatocytes by viral infection and by interferon-α and -γ and mediates T cell apoptosis

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

Gordon J. Freeman, Andrew J. Long, Yoshiko Iwai et al. · The Journal of Experimental Medicine · 2000 · 5.2K citations · Full text

Life Sciences, Immunology, Pathology +17

Restoring function in exhausted CD8 T cells during chronic viral infection

Daniel L. Barber, E. John Wherry, David Masopust et al. · Nature · 2005 · 4K citations

Life Sciences, Immunology, Infectious Diseases +14

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

Yvette Latchman, Clive R. Wood, Tatyana Chernova et al. · Nature Immunology · 2001 · 2.9K citations

Life Sciences, Cell Biology, Immunology +14

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

Haidong Dong, Gefeng Zhu, Koji Tamada et al. · Nature Medicine · 1999 · 2.5K citations

Life Sciences, Cell Biology, Immunology +10

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

Thomas S. Griffith, Thomas Brunner, Sharon M. Fletcher et al. · Science · 1995 · 2K citations

Medicine, Immunology, Ophthalmology +17