Concepedia

Prediction of blood–brain barrier penetration of poorly soluble drug candidates using surface activity profiling

Anna Christine Petereit, Kelly Swinney, J. Mensch, Claire Mackie, Sigrid Stokbroekx, Marcus E. Brewster, Jennifer Dressman

European Journal of Pharmaceutics and Biopharmaceutics · 2010 · 14 citations · 21 references

DOI

Concepts

References

21

Surfactants and interfacial phenomena

Choice Reviews Online · 2005 · 5.4K citations

, , +12

Physicochemical High Throughput Screening:  Parallel Artificial Membrane Permeation Assay in the Description of Passive Absorption Processes

Manfred Kansy, Frank Senner, Klaus Gubernator · Journal of Medicinal Chemistry · 1998 · 1.3K citations

, , +16

High throughput artificial membrane permeability assay for blood–brain barrier

Li Di, Edward H. Kerns, Kristi Fan et al. · European Journal of Medicinal Chemistry · 2003 · 1.1K citations

, , +11

Polar Molecular Surface as a Dominating Determinant for Oral Absorption and Brain Penetration of Drugs

J. Kelder, Peter D. J. Grootenhuis, Denis M. Bayada et al. · Pharmaceutical Research · 1999 · 799 citations

, , +13

Polar Molecular Surface Properties Predict the Intestinal Absorption of Drugs in Humans

Katrin Palm, Patric Stenberg, Kristina Luthman et al. · Pharmaceutical Research · 1997 · 751 citations

, , +14