Concepedia

The application of structure-based assessment to support safety and chemistry diligence to manage genotoxic impurities in active pharmaceutical ingredients during drug development

Krista L. Dobo, Nigel Greene, Michelle O. Cyr, Stéphane Caron, Warren W. Ku

Regulatory Toxicology and Pharmacology · 2006 · 127 citations · 21 references

DOI

Concepts

References

21

Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP

John Ashby, Raymond W. Tennant · Mutation Research/Reviews in Genetic Toxicology · 1991 · 685 citations

, , +15

A rationale for determining, testing, and controlling specific impurities in pharmaceuticals that possess potential for genotoxicity

Lutz Müller, Robert J. Mauthe, Christopher M. Riley et al. · Regulatory Toxicology and Pharmacology · 2006 · 461 citations

, , +12

Computer Prediction of Possible Toxic Action from Chemical Structure; The DEREK System

D. M. Sanderson, C.G. Earnshaw · Human & Experimental Toxicology · 1991 · 369 citations

, , +11

Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man.

Benedetto Terracini · Tumori Journal · 1975 · 311 citations

, , +12

Knowledge-Based Expert Systems for Toxicity and Metabolism Prediction: DEREK, StAR and METEOR

Nigel Greene, Philip N. Judson, J. J. Langowski et al. · SAR and QSAR in environmental research · 1999 · 257 citations

, , +11