Aptamers as a model for functional evaluation of LNA and 2′-amino LNA

High-Resolution Molecular Discrimination by RNA

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LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition

Alexei A. Koshkin, Sanjay K. Singh, Poul Nielsen et al. · Tetrahedron · 1998 · 1K citations

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LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition

Sanjay K. Singh, Alexei A. Koshkin, Jesper Wengel et al. · Chemical Communications · 1998 · 770 citations

Life Sciences, Biotechnology, Molecular Biology +16

Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides

Satoshi Obika, Daishu Nanbu, Yoshiyuki Hari et al. · Tetrahedron Letters · 1998 · 693 citations

Life Sciences, Chemistry, Molecular Biology +16

Application of locked nucleic acids to improve aptamer in vivo stability and targeting function

Kathrin Schmidt · Nucleic Acids Research · 2004 · 279 citations · Full text

Medicine, Molecular Biology, Oncology +16