Smac mimetics increase cancer cell response to chemotherapeutics in a TNF-α-dependent manner

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

Chunying Du, Min Fang, Yucheng Li et al. · Cell · 2000 · 3.5K citations · Full text

Signal Transduction, Mitochondrial Function, Biochemistry +10

An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9

Hua Zou, Yuchen Li, Xuesong Liu et al. · Journal of Biological Chemistry · 1999 · 2.1K citations · Full text

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

Lai Wang, Fenghe Du, Xiaodong Wang · Cell · 2008 · 1.3K citations

Inflammation, Cytokine, Signal Transduction +7

IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

Eugene Varfolomeev, John W. Blankenship, Sarah M. Wayson et al. · Cell · 2007 · 1.2K citations · Full text

Inflammation, Cytokine, Induce Autoubiquitination +12

IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis

James E. Vince, W. Wei‐Lynn Wong, Nufail Khan et al. · Cell · 2007 · 1.1K citations · Full text

Signal Transduction, Signaling Pathway, Medicine +7