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Searching for the Multi-Target-Directed Ligands against Alzheimer’s disease: Discovery of quinoxaline-based hybrid compounds with AChE, H3R and BACE 1 inhibitory activities

Wenhai Huang, Li Tang, Ying Shi, Shufang Huang, Lei Xu, Rong Sheng, Peng Wu, Jia Li, Naiming Zhou, Yongzhou Hu

Bioorganic & Medicinal Chemistry · 2011 · 75 citations · 12 references

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Multi-Target-Directed Drug Design Strategy: From a Dual Binding Site Acetylcholinesterase Inhibitor to a Trifunctional Compound against Alzheimer’s Disease

María Laura Bolognesi, Andrea Cavalli, Luca Valgimigli et al. · Journal of Medicinal Chemistry · 2007 · 258 citations · Full text

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Inhibition of cortical acetylcholine release and cognitive performance by histamine H<sub>3</sub> receptor activation in rats

Patrizio Blandina, Marco Giorgetti, L. Bartolini et al. · British Journal of Pharmacology · 1996 · 229 citations · Full text

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Tacripyrines, the First Tacrine−Dihydropyridine Hybrids, as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease

José Marco‐Contelles, Rafael León, Cristóbal de los Rı́os et al. · Journal of Medicinal Chemistry · 2009 · 134 citations · Full text

, , +17

Design, synthesis and AChE inhibitory activity of indanone and aurone derivatives

Rong Sheng, Yu Xu, Chunqi Hu et al. · European Journal of Medicinal Chemistry · 2008 · 114 citations · Full text

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Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and β-secretase

Yiping Zhu, Kun Xiao, Lanping Ma et al. · Bioorganic & Medicinal Chemistry · 2009 · 102 citations · Full text

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