Concepedia

Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and β-secretase

Yiping Zhu, Kun Xiao, Lanping Ma, Bin Xiong, Yan Fu, Haiping Yu, Wei Wang, Xin Wang, Dingyu Hu, Hongli Peng,

Bioorganic & Medicinal Chemistry · 2009 · 102 citations · 67 references

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Concepts

References

67

Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function

Garrett M. Morris, David S. Goodsell, Robert S. Halliday et al. · Journal of Computational Chemistry · 1998 · 10.8K citations

, , +17

A semiempirical free energy force field with charge‐based desolvation

Ruth Huey, Garrett M. Morris, Arthur J. Olson et al. · Journal of Computational Chemistry · 2007 · 2.2K citations · Full text

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Hydrogen peroxide mediates amyloid β protein toxicity

Christian Behl · Cell · 1994 · 2.1K citations

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BACE1 is the major β-secretase for generation of Aβ peptides by neurons

Huaibin Cai, Yanshu Wang, Diane B. McCarthy et al. · Nature Neuroscience · 2001 · 1.1K citations

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Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation

Yi Luo, Brad Bolon, Steve Kahn et al. · Nature Neuroscience · 2001 · 994 citations

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