Concepedia

Imbalance between Th17 and Treg Cells May Play an Important Role in the Development of Chronic Unpredictable Mild Stress-Induced Depression in Mice

Min Hong, Jie Zheng, Zhaoyun Ding, Junhao Chen, LiangYan Yu, Yan Niu, Yong-qing Hua, Lingling Wang

NeuroImmunoModulation · 2012 · 97 citations · 28 references

DOI

Abstract

These results indicate that in CUMS-induced depression, behavioral changes may closely correlate with the imbalance between Th17 and Treg cell subsets, and TGF-β may be a key regulatory cytokine.

References

28

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

Claire L. Langrish, Yi Chen, Wendy M. Blumenschein et al. · The Journal of Experimental Medicine · 2005 · 4K citations · Full text

Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

Birgit Oppmann, Robin Lesley, Bianca Blom et al. · Immunity · 2000 · 2.8K citations · Full text

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Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant

Paul Willner, Anthony Towell, D. Sampson et al. · Psychopharmacology · 1987 · 1.9K citations

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TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

Liang Zhou, Jared E. Lopes, Mark M. W. Chong et al. · Nature · 2008 · 1.8K citations · Full text

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The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

Mandy J. McGeachy, Yi Chen, Cristina M. Tato et al. · Nature Immunology · 2009 · 1.1K citations · Full text

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