Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors

Identification of a Nuclear Receptor for Bile Acids

Makoto Makishima, Arthur Y. Okamoto, Joyce J. Repa et al. · Science · 1999 · 2.7K citations

Life Sciences, Genetics, Molecular Biology +17

Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

Derek J. Parks, Steven G. Blanchard, Randy K. Bledsoe et al. · Science · 1999 · 2.2K citations

Life Sciences, Biochemistry, Molecular Biology +17

A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis

Bryan Goodwin, Stacey A. Jones, Roger R. Price et al. · Molecular Cell · 2000 · 1.9K citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis

Christopher J. Sinal, Masahiro Tohkin, Masaaki Miyata et al. · Cell · 2000 · 1.8K citations · Full text

Life Sciences, Molecular Biology, Pharmacology +12

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

Kazuhiko Umesono, Kevin K. Murakami, Catherine C. Thompson et al. · Cell · 1991 · 1.7K citations · Full text

Medicine, Genetics, Molecular Genetics +15