Concepedia

Feedback Regulation

Feedback Regulation is a regulatory mechanism within signaling networks wherein the output of a signal transduction pathway modulates the activity of upstream components to either enhance (positive feedback) or suppress (negative feedback) the pathway's activity, thereby maintaining system stability or enabling dynamic cellular responses.

1K

Publications

78.5K

Citations

4.2K

Authors

1.2K

Institutions

Publications per year

2017–2026

174

Parents

Publications

1K

mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt

Kathryn O’Reilly, F. Rojo, Qing‐Bai She et al. · Cancer Research · 2006 · 2.6K citations · Full text

, , +16

Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors

Timothy T. Lu, Makoto Makishima, Joyce J. Repa et al. · Molecular Cell · 2000 · 1.5K citations · Full text

, , +17

Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.

M S Brown, J L Goldstein · Journal of Lipid Research · 1980 · 1.2K citations · Full text

, , +16

Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer

Brett S. Carver, Caren Chapinski, John Wongvipat et al. · Cancer Cell · 2011 · 1.2K citations · Full text

, , +16

A Conserved Network of Transcriptional Activators and Repressors Regulates Anthocyanin Pigmentation in Eudicots

Nick W. Albert, Kevin M. Davies, D. H. LEWIS et al. · The Plant Cell · 2014 · 843 citations · Full text

, , +13

1–5 of 1K

Authors

4.2K

  1. HS
    H. Sira‐Ramírez

    Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico

    8 publications · 317 citations

    8

    h-index

  2. YT
    Yohsuke Takahashi

    The University of Tokyo, Japan

    7 publications · 781 citations

    7

    h-index

  3. SI
    Sarahmi Ishida

    The University of Tokyo, Japan

    5 publications · 497 citations

    5

    h-index

  4. HC
    Ho‐Lim Choi

    Dong-A University, South Korea

    5 publications · 198 citations

    5

    h-index

  5. JG
    Joel G. Belasco

    New York University, United States

    5 publications · 373 citations

    5

    h-index

1–5 of 4.2K

Institutions

1.2K

  1. Harvard University

    Cambridge, United States

    23 h-index

    76 publications

    5.4K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    18 h-index

    60 publications

    7.3K citations

  3. Stanford University

    Stanford, United States

    16 h-index

    55 publications

    7.3K citations

  4. Cornell University

    Ithaca, United States

    15 h-index

    55 publications

    7.8K citations

  5. Howard Hughes Medical Institute

    Chevy Chase, United States

    15 h-index

    40 publications

    13.5K citations

  6. Chinese Academy of Sciences

    Beijing, China

    14 h-index

    59 publications

    2K citations

  7. University of Wisconsin–Madison

    Madison, United States

    13 h-index

    29 publications

    1.6K citations

  8. University of Michigan

    Ann Arbor, United States

    13 h-index

    34 publications

    2.5K citations

1–8 of 1.2K

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 48 publications · 6.6K citations

    37

    h-index

  2. Journal of Biological Chemistry

    JBC · 46 publications · 3.5K citations

    35

    h-index

  3. Endocrinology

    34 publications · 2K citations

    25

    h-index

  4. PLANT PHYSIOLOGY

    28 publications · 4.3K citations

    23

    h-index

  5. PubMed

    Repository · 25 publications · 869 citations

    18

    h-index

1–5