Achieving structural diversity using the perpendicular conformation of alpha-substituted phenylcyclopropanes to mimic the bioactive conformation of ortho-substituted biphenyl P4 moieties: Discovery of novel, highly potent inhibitors of Factor Xa

Publication | Open Access

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References

2008

Year

Jennifer X. Qiao, Daniel L. Cheney, Richard Alexander, Angela Smallwood, Sarah R. King, Kan He, Alan R. Rendina, Joseph M. Luettgen, Robert M. Knabb, Ruth R. Wexler,

Bioorganic & Medicinal Chemistry Letters

Bioactive ConformationMedicinal ChemistryHeterocyclicBiochemistryNatural SciencesMedicinePerpendicular ConformationOrganic ChemistryFactor XaHeterocycle ChemistryPharmacologyDrug Discovery