Epigallocatechin‐3‐Gallate suppresses early stage, but not late stage prostate cancer in TRAMP mice: Mechanisms of action

Abstract

The attenuation of the AR, the down-regulation of potent growth factor IGF-1, modulation of inflammation biomarkers, and decrease in the MAPK signaling may contribute to the reduction in cell proliferation and induction of apoptosis and hence provide a biochemical basis for EGCG suppressing PCa without toxicity.