Publication | Closed Access
A Rapid Total Synthesis of Spirotryprostatin B: Proof of Its Relative and Absolute Stereochemistry
117
Citations
7
References
2000
Year
Bioorganic ChemistryMolecular BiologyChemical BiologyMedicinal ChemistryNucleic Acid ChemistryCytostatic 1Mannich-insertion StrategyStereoselective SynthesisAbsolute StereochemistrySpirotryprostatin BRapid Total SynthesisBiochemistryBioconjugationOligonucleotidePharmacologyNatural Product SynthesisNatural SciencesMedicineRelative StereochemistryDrug Discovery
A Mannich-insertion strategy was employed in the synthesis of cytostatic 1. The synthesis allowed the absolute and relative stereochemistry to be confirmed and yielded quantities of 1 suitable for upcoming biological testing. Boc=tert-butoxycarbonyl.
| Year | Citations | |
|---|---|---|
Page 1
Page 1