Concepedia

Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia

Steven M. Chan, Danièl Thomas, M. Ryan Corces, Seethu Xavy, Suchita Rastogi, Wan‐Jen Hong, Feifei Zhao, Bruno C. Medeiros, David A. Tyvoll, Ravindra Majeti

Nature Medicine · 2015 · 570 citations · 53 references

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53

<i>IDH1</i>and<i>IDH2</i>Mutations in Gliomas

Hai Yan, D. Williams Parsons, Genglin Jin et al. · New England Journal of Medicine · 2009 · 5.9K citations · Full text

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An Integrated Genomic Analysis of Human Glioblastoma Multiforme

D. Williams Parsons, Siân Jones, Xiaosong Zhang et al. · Science · 2008 · 5.8K citations · Full text

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Lenny Dang, David W. White, Bryson D. Bennett et al. · Nature · 2009 · 4.1K citations · Full text

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Bcl-2 functions in an antioxidant pathway to prevent apoptosis

David M. Hockenbery, Zoltán N. Oltvai, Xiao-Ming Yin et al. · Cell · 1993 · 3.4K citations

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ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

Andrew J. Souers, Joel D. Leverson, Erwin R. Boghaert et al. · Nature Medicine · 2013 · 3K citations

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