Steven M. Chan

Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution

M. Ryan Corces, Jason D. Buenrostro, Beijing Wu et al. · Nature Genetics · 2016 · 1.3K citations · Full text

Hematological Malignancy, Chromatin, Chromatin Structure +12

Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia

Steven M. Chan, Danièl Thomas, M. Ryan Corces et al. · Nature Medicine · 2015 · 563 citations · Full text

Hematological Malignancy, Isocitrate Dehydrogenase 1, Mixed-phenotype Acute Leukemia +7

Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia

Steven M. Chan, Andrew P. Weng, Robert Tibshirani et al. · Blood · 2007 · 280 citations · Full text

Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation

Claire Mazumdar, Ying Shen, Seethu Xavy et al. · Cell stem cell · 2015 · 206 citations · Full text

Developmental Biology, Medicine, Stem Cell Mobilization +8

Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response

David Sharon, Séverine Cathelin, Sara Mirali et al. · Science Translational Medicine · 2019 · 193 citations

Mitochondrial Translation Overcomes, Cellular Physiology, Oxidative Stress +17