Concepedia

Pyrazolopyridines as potent PDE4B inhibitors: 5-Heterocycle SAR

Charlotte Mitchell, Stuart P. Ballantine, Diane M. Coe, Caroline M. Cook, C. J. Delves, Mike D. Dowle, Chris D. Edlin, J. Hamblin, Stuart Holman, Martin R. Johnson,

Bioorganic & Medicinal Chemistry Letters · 2010 · 40 citations · 5 references

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Concepts

References

5

Phosphodiesterase 4B2 Is the Predominant Phosphodiesterase Species and Undergoes Differential Regulation of Gene Expression in Human Monocytes and Neutrophils

Peng Wang, Ping Wu, Kathleen M. Ohleth et al. · Molecular Pharmacology · 1999 · 169 citations

, , +16

Identification, characterization and functional role of phosphodiesterase isozymes in human airway smooth muscle.

Theodore J. Torphy, Bradley J. Undem, L B Cieslinski et al. · Journal of Pharmacology and Experimental Therapeutics · 1993 · 165 citations

, , +14

Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors

J. Hamblin, Tony D. Angell, Stuart P. Ballantine et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 71 citations · Full text

, , +14

Synthesis of Malarial Plasmepsin Inhibitors and Prediction of Binding Modes by Molecular Dynamics Simulations

Karolina Ersmark, Martin Nervall, Elizabeth Hamelink et al. · Journal of Medicinal Chemistry · 2005 · 64 citations · Full text

, , +17

Novel 5,6-dihydropyrazolo-[3,4-E][1,4]diazepin-4 (1H)-one derivatives for the treatment of asthma and chronic obstructive pulmonary disease

Hazel J. Dyke · Expert Opinion on Therapeutic Patents · 2007 · 11 citations

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