Concepedia

Silibinin meglumine, a water-soluble form of milk thistle silymarin, is an orally active anti-cancer agent that impedes the epithelial-to-mesenchymal transition (EMT) in EGFR-mutant non-small-cell lung carcinoma cells

Sílvia Cufí, Rosa Bonavia, Alejandro Vázquez‐Martín, Bruna Corominas-Faja, Cristina Oliveras‐Ferraros, Elisabet Cuyàs, Begoña Martı́n-Castillo, Enrique Barrajón‐Catalán, Joana Visa, Antonio Segura‐Carretero,

Food and Chemical Toxicology · 2013 · 64 citations · 39 references

DOI

Concepts

References

39

Dose translation from animal to human studies revisited

Shannon Reagan‐Shaw, Minakshi Nihal, Nihal Ahmad · The FASEB Journal · 2007 · 6.3K citations

, , +13

Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer

Zhenfeng Zhang, Jae Cheol Lee, Luping Lin et al. · Nature Genetics · 2012 · 1.2K citations

, , +16

An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Lauren A. Byers, Lixia Diao, Jing Wang et al. · Clinical Cancer Research · 2012 · 1.1K citations · Full text

, , +17

Epithelial to Mesenchymal Transition Is a Determinant of Sensitivity of Non–Small-Cell Lung Carcinoma Cell Lines and Xenografts to Epidermal Growth Factor Receptor Inhibition

Stuart Thomson, Elizabeth Buck, Filippo Petti et al. · Cancer Research · 2005 · 672 citations

, , +17

Epithelial versus Mesenchymal Phenotype Determines <i>In vitro</i> Sensitivity and Predicts Clinical Activity of Erlotinib in Lung Cancer Patients

Robert L. Yauch, Thomas Januario, David A. Eberhard et al. · Clinical Cancer Research · 2005 · 491 citations · Full text

, , +17