Concepedia

A single replacement of histidine to arginine in EGFR-lytic hybrid peptide demonstrates the improved anticancer activity

Noriko Tada, Tomohisa Horibe, Mari Haramoto, Koji Ohara, Masayuki Kohno, Koji Kawakami

Biochemical and Biophysical Research Communications · 2011 · 35 citations · 19 references

Concepts

PharmacyMedicinal ChemistryOncologyDrug DiscoveryMolecular OncologyProtein EngineeringCancer ImmunotherapyPeptide ChemistryPeptide Drug DiscoveryPeptidomimetic DesignTargeted Cancer TherapyTyrosine Kinase InhibitorsAnticancer ActivityArginine-rich PeptidesBioactive Peptide MimicsEgfr InhibitionEpidermal Growth Factor Receptor Targeting LigandsTherapeutic PeptidesTumor-targeting Peptides

References

19

Antimicrobial peptides of multicellular organisms

Michael Zasloff · Nature · 2002 · 8.4K citations

Life Sciences, Biochemistry, Microbiology +10

<i>K-ras</i> Mutations and Benefit from Cetuximab in Advanced Colorectal Cancer

Christos S. Karapetis, Shirin Khambata‐Ford, Derek J. Jonker et al. · New England Journal of Medicine · 2008 · 3.6K citations

Medicine, Oncology, Pharmacology +17

Arginine-rich Peptides

Shiroh Futaki, Tomoki Suzuki, Wakana Ohashi et al. · Journal of Biological Chemistry · 2001 · 1.7K citations · Full text

Life Sciences, Biochemistry, Gene Expression +9

Anti-cancer activity of targeted pro-apoptotic peptides

H. Michael Ellerby, Wadih Arap, Lisa Ellerby et al. · Nature Medicine · 1999 · 930 citations

Life Sciences, Oncology, Pharmacology +14

<i>PIK3CA</i> Mutations in Colorectal Cancer Are Associated with Clinical Resistance to EGFR-Targeted Monoclonal Antibodies

Andrea Sartore‐Bianchi, Miriam Martini, Francesca Molinari et al. · Cancer Research · 2009 · 739 citations

Medicine, Oncology, Pharmacology +17