Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis

Wendy De Roock, Bart Claes, David Bernasconi, +34

The Lancet Oncology

Retrospective Consortium AnalysisMedicinePathologyColorectal CancerPik3ca Mutations +3

Wild-Type <i>BRAF</i> Is Required for Response to Panitumumab or Cetuximab in Metastatic Colorectal Cancer

Federica Di Nicolantonio, Miriam Martini, Francesca Molinari, +8

Journal of Clinical Oncology

Kras MutationsGastrointestinal OncologyMedicineBraf MutationsImmunology +11

<i>PIK3CA</i> Mutations in Colorectal Cancer Are Associated with Clinical Resistance to EGFR-Targeted Monoclonal Antibodies

Andrea Sartore‐Bianchi, Miriam Martini, Francesca Molinari, +10

Cancer Research

Side KrasPathologyTumor BiologyOncologyClinical Resistance +15

Multi-Determinants Analysis of Molecular Alterations for Predicting Clinical Benefit to EGFR-Targeted Monoclonal Antibodies in Colorectal Cancer

Andrea Sartore‐Bianchi, Federica Di Nicolantonio, Michele Nichelatti, +12

PLoS ONE

Measurement of PIP3 Levels Reveals an Unexpected Role for p110β in Early Adaptive Responses to p110α-Specific Inhibitors in Luminal Breast Cancer

Carlotta Costa, Hiromichi Ebi, Miriam Martini, +12

Cancer Cell

Breast OncologyOncologyMedicinePharmacologyCancer Cell Biology +8

Phosphoinositide 3-Kinase Gamma Inhibition Protects From Anthracycline Cardiotoxicity and Reduces Tumor Growth

Mingchuan Li, Valentina Sala, Maria Chiara De Santis, +30

Circulation

PI3K Class II α Controls Spatially Restricted Endosomal PtdIns3P and Rab11 Activation to Promote Primary Cilium Function

Irene Franco, Federico Gulluni, Carlo Cosimo Campa, +16

Developmental Cell

Protective effect of the tunneling nanotube-TNFAIP2/M-sec system on podocyte autophagy in diabetic nephropathy

Federica Barutta, Stefania Bellini, Shunsuke Kimura, +14

Autophagy

Replacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responses

Federica Di Nicolantonio, Sabrina Arena, Margherita Gallicchio, +12

Proceedings of the National Academy of Sciences

GeneticsMutated CellsMolecular GeneticsCancer BiologyTumor Biology +20

Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function

Federico Gulluni, Miriam Martini, Maria Chiara De Santis, +23

Cancer Cell

ChromatinChromatin StructureCell DivisionGenomic StabilityNatural Sciences +10