Concepedia

α,α′-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes

James L. Galman, David Steadman, Sarah Bacon, Phattaraporn Morris, Mark E. B. Smith, John M. Ward, Paul A. Dalby

Chemical Communications · 2010 · 52 citations · 28 references

DOI

Concepts

Abstract

Transketolase mutants have been identified that accept aromatic acceptors with good stereoselectivities, in particular benzaldehyde for which the wild type enzyme showed no activity.

References

28

Substrate spectrum of ω-transaminase from Chromobacterium violaceum DSM30191 and its potential for biocatalysis

Ursula Kaulmann, Kirsty Smithies, Mark E. B. Smith et al. · Enzyme and Microbial Technology · 2007 · 309 citations

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Substrate specificity and carbohydrate synthesis using transketolase

Yoshihiro Kobori, David C. Myles, George M. Whitesides · The Journal of Organic Chemistry · 1992 · 164 citations

, , +11

The oxidative pentose phosphate cycle. I. Preparation of substrates and enzymes

Paul A. Srere, J. R. Cooper, Milton Tabachnick et al. · Archives of Biochemistry and Biophysics · 1958 · 148 citations

, , +10

One‐pot synthesis of amino‐alcohols using a de‐novo transketolase and β‐alanine: Pyruvate transaminase pathway in <i>Escherichia coli</i>

Christine Ursula Ingram, Martin Bommer, Mark E. B. Smith et al. · Biotechnology and Bioengineering · 2006 · 143 citations

, , +17

Examination of Substrate Binding in Thiamin Diphosphate- dependent Transketolase by Protein Crystallography and Site-directed Mutagenesis

Ulrika Nilsson, L. E. Meshalkina, Ylva Lindqvist et al. · Journal of Biological Chemistry · 1997 · 129 citations · Full text

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