David Steadman

Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells

Jonathan Powell, Filipa Mota, David Steadman et al. · Journal of Medicinal Chemistry · 2018 · 80 citations · Full text

Structure of Human Thymidylate Synthase Suggests Advantages of Chemotherapy with Noncompetitive Inhibitors

Jason Phan, David Steadman, Sangita Koli et al. · Journal of Biological Chemistry · 2001 · 76 citations · Full text

Crystal Structure, Protein Assembly, Molecular Biology +19

DNA-binding sequence of the human prostate-specific homeodomain protein NKX3.1

David Steadman · Nucleic Acids Research · 2000 · 73 citations · Full text

Protein Function, Signal Transduction, Signaling Pathway +11

α,α′-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes

James L. Galman, David Steadman, Sarah Bacon et al. · Chemical Communications · 2010 · 52 citations

Evolved Transketolase Enzymes, Engineering, Molecular Biology +17

Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling

Elliott D. Bayle, Fredrik Svensson, Benjamin N. Atkinson et al. · Journal of Medicinal Chemistry · 2021 · 48 citations · Full text