Synthesis and structure based optimization of novel Akt inhibitors

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

John D. Carpten, Andrew L. Faber, Candice L. Horn et al. · Nature · 2007 · 1.3K citations

Medicine, Molecular Biology, Oncology +12

Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

Craig W. Lindsley, Zhijian Zhao, William Leister et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 501 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Potent and selective inhibitors of Akt kinases slow the progress of tumors <i>in vivo</i>

Yan Luo, Alexander R. Shoemaker, Xuesong Liu et al. · Molecular Cancer Therapeutics · 2005 · 244 citations · Full text

Medicine, Oncology, Pharmacology +15

Retracted: Frequent genetic and biochemical alterations of the PI 3‐K/AKT/PTEN pathway in head and neck squamous cell carcinoma

Juana García-Pedrero, Dario Garcia Carracedo, Cristina Muñoz Pinto et al. · International Journal of Cancer · 2004 · 231 citations

Medicine, Genetics, Oncology +17

Novel PI Analogues Selectively Block Activation of the Pro-survival Serine/Threonine Kinase Akt

Alan P. Kozikowski, Haiying Sun, John Brognard et al. · Journal of the American Chemical Society · 2003 · 197 citations

Life Sciences, Biochemistry, Pharmacology +13