Discovery of micromolar PDE IV inhibitors that exhibit much reduced affinity for the [3H]rolipram binding site: 3-norbornyloxy-4-methoxyphenylmethylene oxindoles

Coexpression of human cAMP-specific phosphodiesterase activity and high affinity rolipram binding in yeast.

Theodore J. Torphy, Jeffrey M. Stadel, Miriam Burman et al. · Journal of Biological Chemistry · 1992 · 139 citations · Full text

Proteinlipid Interaction, Signal Transduction, Biochemistry +14

Selective Type IV Phosphodiesterase Inhibitors as Antiasthmatic Agents. The Syntheses and Biological Activities of 3-(Cyclopentyloxy)-4-methoxybenzamides and Analogs

Michael J. Ashton, David Cook, Garry Fenton et al. · Journal of Medicinal Chemistry · 1994 · 112 citations · Full text

Antiparasitic Agent, Pde Iv, Biological Activities +17

Anti‐inflammatory and bronchodilator properties of RP 73401, a novel and selective phosphodiesterase type IV inhibitor

David Raeburn, Stephen L. Underwood, S.A. Lewis et al. · British Journal of Pharmacology · 1994 · 109 citations · Full text

Bronchodilatory effect of inhaled zardaverine, a phosphodiesterase III and IV inhibitor, in patients with asthma

Tilo Brunnée, Renate Engelstätter, VW Steinijans et al. · European Respiratory Journal · 1992 · 81 citations · Full text

Asthma, Molecular Pharmacology, Allergy +15

Calcium-independent phosphodiesterase inhibitors as putative antidepressants: [3-(bicycloalkyloxy)-4-methoxyphenyl-2-imidazolidinones

Nicholas A. Saccomano, Fredric J. Vinick, B. Kenneth Koe et al. · Journal of Medicinal Chemistry · 1991 · 48 citations · Full text