Biarylcarboxylic Acids and -amides:  Inhibition of Phosphodiesterase Type IV versus [³H]Rolipram Binding Activity and Their Relationship to Emetic Behavior in the Ferret

Allen J. Duplantier, Michael S. Biggers, Robert Chambers, +11

Journal of Medicinal Chemistry

A stereoselective synthesis of functionalized alkenyllithiums and alkenyl cyanocuprates by the copper(I)-catalyzed coupling of organolithium reagents with .alpha.-lithiated cyclic enol ethers

Philip Kocieński, Sjoerd Wadman, Kelvin Cooper

Journal of the American Chemical Society

Chemical EngineeringCross-coupling ReactionEngineeringKelvin CooperciteAltmetric Attention Score +10

1,4-Dihydropyridines as antagonists of platelet activating factor. 1. Synthesis and structure-activity relationships of 2-(4-heterocyclyl)phenyl derivatives

Kelvin Cooper, M. Jonathan Fray, M. J. PARRY, +2

Journal of Medicinal Chemistry

Pharmaceutical ScienceCompound 17Organic ChemistryPharmacotherapyHeterocycle Chemistry +16

Discovery of the Hemifumarate and (α-<scp>l</scp>-Alanyloxy)methyl Ether as Prodrugs of an Antirheumatic Oxindole:  Prodrugs for the Enolic OH Group

Ralph P. Robinson, Lawrence A. Reiter, Wayne E. Barth, +16

Journal of Medicinal Chemistry

Pharmaceutical ScienceBioorganic ChemistryAntirheumatic OxindolePharmacotherapyExperimental Pharmacology +20

Synthesis and in vitro profile of a novel series of catechol benzimidazoles. The discovery of potent, selective phosphodiesterase type IV inhibitors with greatly attenuated affinity for the [3H]rolipram binding site

John B. Cheng, Kelvin Cooper, Allen J. Duplantier, +8

Bioorganic & Medicinal Chemistry Letters

Catechol BenzimidazolesMedicinal ChemistryNovel SeriesBiochemistryNatural Sciences +9

Novel Antagonists of Platelet-Activating Factor. 1. Synthesis and Structure-Activity Relationships of Benzodiazepine and Benzazepine Derivatives of 2-Methyl-1-phenylimidazo[4,5-c]pyridine

M J Fray, Kelvin Cooper, M. J. PARRY, +2

Journal of Medicinal Chemistry

Pharmaceutical ScienceBenzazepine DerivativesPlatelet-activating FactorPharmacotherapyExperimental Pharmacology +16

A highly stereoselective and iterative approach to isoprenoid chains: synthesis of homogeraniol, homofarnesol, and homogeranylgeraniol

Philip Kocieński, Sjoerd Wadman, Kelvin Cooper

The Journal of Organic Chemistry

BiosynthesisMolecular SciencesEngineeringBiochemistryDonut Icon +11

In vitro activity of 2-alkyl-3-hydroxy-1,4-naphthoquinones against Theileria parva

Peter Boehm, Kelvin Cooper, Alan T. Hudson, +2

Journal of Medicinal Chemistry

BiochemistryAntiparasitic AgentMedicineStructure-activity StudiesAntimicrobial Compound +6

Parathyroid hormone-related peptide production and action in a myoepithelial cell line derived from normal human breast.

Patricia K. Seitz, Kelvin Cooper, Kirk L. Ives, +4

Endocrinology

An efficient and stereoselective synthesisi of homoallylic alcohols via nickel-catalysed coupling of 5-alkyl-2,3-dihydrofurans with Grignard reagents

Sjoerd Wadman, Richard J. Whitby, Clive Yeates, +2

Journal of the Chemical Society Chemical Communications

Cross-coupling ReactionEngineeringStereoselective SynthesisiGrignard ReagentsStereoselective Method +9