Kelvin Cooper

Biarylcarboxylic Acids and -amides:  Inhibition of Phosphodiesterase Type IV versus [³H]Rolipram Binding Activity and Their Relationship to Emetic Behavior in the Ferret

Allen J. Duplantier, Michael S. Biggers, Robert Chambers et al. · Journal of Medicinal Chemistry · 1996 · 143 citations · Full text

A stereoselective synthesis of functionalized alkenyllithiums and alkenyl cyanocuprates by the copper(I)-catalyzed coupling of organolithium reagents with .alpha.-lithiated cyclic enol ethers

Philip Kocieński, Sjoerd Wadman, Kelvin Cooper · Journal of the American Chemical Society · 1989 · 109 citations

Chemical Engineering, Cross-coupling Reaction, Engineering +12

1,4-Dihydropyridines as antagonists of platelet activating factor. 1. Synthesis and structure-activity relationships of 2-(4-heterocyclyl)phenyl derivatives

Kelvin Cooper, M. Jonathan Fray, M. J. PARRY et al. · Journal of Medicinal Chemistry · 1992 · 101 citations · Full text

Pharmaceutical Science, Compound 17, Organic Chemistry +18

Discovery of the Hemifumarate and (α-<scp>l</scp>-Alanyloxy)methyl Ether as Prodrugs of an Antirheumatic Oxindole:  Prodrugs for the Enolic OH Group

Ralph P. Robinson, Lawrence A. Reiter, Wayne E. Barth et al. · Journal of Medicinal Chemistry · 1996 · 75 citations

Pharmaceutical Science, Bioorganic Chemistry, Antirheumatic Oxindole +22

Synthesis and in vitro profile of a novel series of catechol benzimidazoles. The discovery of potent, selective phosphodiesterase type IV inhibitors with greatly attenuated affinity for the [3H]rolipram binding site

John B. Cheng, Kelvin Cooper, Allen J. Duplantier et al. · Bioorganic & Medicinal Chemistry Letters · 1995 · 45 citations

Catechol Benzimidazoles, Medicinal Chemistry, Novel Series +11