John T. Shirley

Biarylcarboxylic Acids and -amides:  Inhibition of Phosphodiesterase Type IV versus [³H]Rolipram Binding Activity and Their Relationship to Emetic Behavior in the Ferret

Allen J. Duplantier, Michael S. Biggers, Robert Chambers et al. · Journal of Medicinal Chemistry · 1996 · 143 citations · Full text

Striking Effect of Hydroxamic Acid Substitution on the Phosphodiesterase Type 4 (PDE4) and TNFα Inhibitory Activity of Two Series of Rolipram Analogues:  Implications for a New Active Site Model of PDE4

Edward F. Kleinman, Erin Campbell, L. GIORDANO et al. · Journal of Medicinal Chemistry · 1998 · 55 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Molecular Sciences +12

Synthesis and in vitro profile of a novel series of catechol benzimidazoles. The discovery of potent, selective phosphodiesterase type IV inhibitors with greatly attenuated affinity for the [3H]rolipram binding site

John B. Cheng, Kelvin Cooper, Allen J. Duplantier et al. · Bioorganic & Medicinal Chemistry Letters · 1995 · 45 citations

Catechol Benzimidazoles, Medicinal Chemistry, Novel Series +11

Discovery of micromolar PDE IV inhibitors that exhibit much reduced affinity for the [3H]rolipram binding site: 3-norbornyloxy-4-methoxyphenylmethylene oxindoles

Hiroko Masamune, John B. Cheng, Kelvin Cooper et al. · Bioorganic & Medicinal Chemistry Letters · 1995 · 29 citations

Molecular Pharmacology, 3-Norbornyloxy-4-methoxyphenylmethylene Oxindoles, Drug Target +9

Antigen-mediated pulmonary eosinophilia in immunoglobulin G1-sensitized guinea pigs: eosinophil peroxidase as a simple specific marker for detecting eosinophils in bronchoalveolar lavage fluid.

John B. Cheng, J. Pillar, John T. Shirley et al. · Journal of Pharmacology and Experimental Therapeutics · 1993 · 21 citations