Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1

Mutations in the <i>SMAD4/DPC4</i> Gene in Juvenile Polyposis

James R. Howe, Stina Roth, John C. Ringold et al. · Science · 1998 · 897 citations

Life Sciences, Genetics, Molecular Genetics +17

QuantiSNP: an Objective Bayes Hidden-Markov Model to detect and accurately map copy number variation using SNP genotyping data

Stefano Colella, Christopher Yau, Jennifer M. Taylor et al. · Nucleic Acids Research · 2007 · 627 citations · Full text

Life Sciences, Bioinformatics, Genetics +17

Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis

James R. Howe, Jennifer Bair, Mohamed G. Sayed et al. · Nature Genetics · 2001 · 624 citations

Life Sciences, Genetics, Molecular Genetics +15

Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors

Cynthia Kosinski, Vivian Li, Annie S Y Chan et al. · Proceedings of the National Academy of Sciences · 2007 · 580 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Allelic Variation in Gene Expression Is Common in the Human Genome

H. Shuen Lo, Zhining Wang, Ying Hu et al. · Genome Research · 2003 · 449 citations · Full text

Life Sciences, Genetics, Molecular Genetics +16