Stefania Segditsas

Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1

Emma Jaeger, Simon J. Leedham, Annabelle Lewis et al. · Nature Genetics · 2012 · 278 citations · Full text

Bmp Antagonist Grem1, Allelic Variant, Autoimmune Disease +9

PHLDA1 Expression Marks the Putative Epithelial Stem Cells and Contributes to Intestinal Tumorigenesis

Anuratha Sakthianandeswaren, Michael Christie, Carla D'Andreti et al. · Cancer Research · 2011 · 98 citations

Tumor Biology, Crypt Base, Lineage Plasticity +15

A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts

Simon J. Leedham, Pedro Rodenas-Cuadrado, Kimberley Howarth et al. · Gut · 2012 · 91 citations · Full text

Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice

Stefania Segditsas, Oliver M. Sieber, Maesha Deheragoda et al. · Human Molecular Genetics · 2008 · 79 citations · Full text

New Genes, Systems Biology, Mouse Adenomas +13

APC and the three-hit hypothesis

Stefania Segditsas, Andrew Rowan, Kimberley Howarth et al. · Oncogene · 2008 · 68 citations

Engineering, Imprecise Probability, Probability Theory +3