Stefania Segditsas

Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1

Emma Jaeger, Simon J. Leedham, Annabelle Lewis et al. · Nature Genetics · 2012 · 281 citations · Full text

Life Sciences, Genetics, Molecular Biology +5

PHLDA1 Expression Marks the Putative Epithelial Stem Cells and Contributes to Intestinal Tumorigenesis

Anuratha Sakthianandeswaren, Michael Christie, Carla D'Andreti et al. · Cancer Research · 2011 · 99 citations

Medicine, Cell Biology, Oncology +17

A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts

Simon J. Leedham, Pedro Rodenas-Cuadrado, Kimberley Howarth et al. · Gut · 2012 · 94 citations · Full text

Medicine, Cell Biology, Oncology +17

Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice

Stefania Segditsas, Oliver M. Sieber, Maesha Deheragoda et al. · Human Molecular Genetics · 2008 · 79 citations · Full text

Medicine, Molecular Genetics, Oncology +17

APC and the three-hit hypothesis

Stefania Segditsas, Andrew Rowan, Kimberley Howarth et al. · Oncogene · 2008 · 68 citations

Medicine, Molecular Genetics, Apoptosis +1