Simon J. Leedham

Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission

Laura C. Greaves, Sean Preston, Paul Tadrous et al. · Proceedings of the National Academy of Sciences · 2006 · 294 citations · Full text

Life Sciences, Biology, Genetics +13

Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche

Hayley L. Belnoue-Davis, Shazia Irshad, Mukesh Bansal et al. · Nature Medicine · 2014 · 285 citations

Medicine, Cancer Biology, Oncology +16

Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1

Emma Jaeger, Simon J. Leedham, Annabelle Lewis et al. · Nature Genetics · 2012 · 281 citations · Full text

Life Sciences, Genetics, Molecular Biology +5

Association analyses identify 31 new risk loci for colorectal cancer susceptibility

Philip Law, Maria Timofeeva, Ceres Fernández–Rozadilla et al. · Nature Communications · 2019 · 272 citations · Full text

Life Sciences, Genetics, Molecular Genetics +16

Image-based consensus molecular subtype (imCMS) classification of colorectal cancer using deep learning

Korsuk Sirinukunwattana, Enric Domingo, Susan D. Richman et al. · Gut · 2020 · 272 citations · Full text

Medicine, Oncology, Pathology +17