Simon J. Leedham

Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission

Laura C. Greaves, Sean Preston, Paul Tadrous et al. · Proceedings of the National Academy of Sciences · 2006 · 293 citations · Full text

Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche

Hayley L. Belnoue-Davis, Shazia Irshad, Mukesh Bansal et al. · Nature Medicine · 2014 · 284 citations · Full text

Lineage Plasticity, Medicine, Colorectal Cancer +10

Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1

Emma Jaeger, Simon J. Leedham, Annabelle Lewis et al. · Nature Genetics · 2012 · 278 citations · Full text

Bmp Antagonist Grem1, Allelic Variant, Autoimmune Disease +9

Association analyses identify 31 new risk loci for colorectal cancer susceptibility

Philip Law, Maria Timofeeva, Ceres Fernández–Rozadilla et al. · Nature Communications · 2019 · 265 citations · Full text

Image-based consensus molecular subtype (imCMS) classification of colorectal cancer using deep learning

Korsuk Sirinukunwattana, Enric Domingo, Susan D. Richman et al. · Gut · 2020 · 258 citations · Full text