Estrogen blocks neurotoxic effects of β-amyloid (1–42) and induces neurite extension on B103 cells

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Alison Goate, Marie‐Christine Chartier‐Harlin, Jeremy Brown et al. · Nature · 1991 · 4.6K citations

Life Sciences, Genetics, Molecular Genetics +16

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

Karen Hsiao, Paul F. Chapman, Steven P. Nilsen et al. · Science · 1996 · 4.2K citations

Life Sciences, Neurobiology, Neuroscience +17

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Donalyn Scheuner, Christopher B. Eckman, M. Jensen et al. · Nature Medicine · 1996 · 2.6K citations

Life Sciences, Neurobiology, Neuroscience +16

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

Bruce A. Yankner, Lawrence K. Duffy, Daniel A. Kirschner · Science · 1990 · 2K citations

Life Sciences, Neurobiology, Neuroscience +17

Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease

Ming‐Xin Tang, Diane M. Jacobs, Yaakov Stern et al. · The Lancet · 1996 · 1.6K citations

Medicine, Endocrinology, Geriatric Medicine +12