Concepedia

Assessing the lipophilicity of fragments and early hits

Paul N. Mortenson, Christopher W. Murray

Journal of Computer-Aided Molecular Design · 2011 · 108 citations · 11 references

DOI

Concepts

References

11

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11.2K citations

, , +16

The maximal affinity of ligands

Irwin D. Kuntz, K. Chen, Kim A. Sharp et al. · Proceedings of the National Academy of Sciences · 1999 · 845 citations

, , +16

A Comparison of Physiochemical Property Profiles of Development and Marketed Oral Drugs

Mark C. Wenlock, Rupert P. Austin, Patrick Barton et al. · Journal of Medicinal Chemistry · 2003 · 537 citations

, , +17

Ligand efficiency indices as guideposts for drug discovery

C ABADZAPATERO · Drug Discovery Today · 2005 · 523 citations

, , +14

Ligand Binding Efficiency: Trends, Physical Basis, and Implications

Charles H. Reynolds, Brett A. Tounge, Scott D. Bembenek · Journal of Medicinal Chemistry · 2008 · 318 citations

, , +15