Concepedia

Dipeptidyl α-fluorovinyl Michael acceptors: Synthesis and activity against cysteine proteases

Koen Steert, Ibrahim El Tantawy El Sayed, Pieter Van der Veken, Alisa Krishtal, Christian Van Alsenoy, Gareth D. Westrop, Jeremy C. Mottram, Graham H. Coombs, Koen Augustyns, Achiel Haemers

Bioorganic & Medicinal Chemistry Letters · 2007 · 32 citations · 15 references

DOI

Concepts

References

15

Bonded-atom fragments for describing molecular charge densities

F. L. Hirshfeld · Theoretical Chemistry Accounts · 1977 · 6.9K citations

, , +14

Vinyl Sulfones as Mechanism-Based Cysteine Protease Inhibitors

James T. Palmer, David Rasnick, Jeffrey L. Klaus et al. · Journal of Medicinal Chemistry · 1995 · 506 citations · Full text

, , +6

Cysteine Protease Inhibitors Cure an Experimental <i>Trypanosoma cruzi</i> Infection

Juan C. Engel, Patricia S. Doyle, Ivy Hsieh et al. · The Journal of Experimental Medicine · 1998 · 383 citations · Full text

, , +15

Structure-Activity Relationships for Inhibition of Cysteine Protease Activity and Development of <i>Plasmodium falciparum</i> by Peptidyl Vinyl Sulfones

Bhaskar R. Shenai, Belinda J. Lee, Alejandro Álvarez‐Hernández et al. · Antimicrobial Agents and Chemotherapy · 2002 · 159 citations · Full text

, , +15

Relative Rates of Michael Reactions of 2‘-(Phenethyl)thiol with Vinyl Sulfones, Vinyl Sulfonate Esters, and Vinyl Sulfonamides Relevant to Vinyl Sulfonyl Cysteine Protease Inhibitors

Jason J. Reddick, Jianming Cheng, William Roush · Organic Letters · 2003 · 118 citations

, , +13