An Efficient Synthesis of 3-Substituted 3<i>H</i>-Pyrimidin-4-ones

Abstract

[reaction: see text] A novel and practical synthesis of 3-substituted 3H-pyrimidin-4-ones is described. The key step involves the cyclization of enamide esters, derived from readily available beta-keto esters, with trimethylaluminum and various primary amines.