Concepedia

Glutathione selectively inhibits Doxorubicin induced phosphorylation of p53Ser15, caspase dependent ceramide production and apoptosis in human leukemic cells

Faisal Thayyullathil, Shahanas Chathoth, Jaleel Kizhakkayil, Alaa Galadari, Abdulkader Hago, Mahendra Patel, Sehamuddin Galadari

Biochemical and Biophysical Research Communications · 2011 · 12 citations · 29 references

DOI

Concepts

References

29

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.

Adriana Haimovitz‐Friedman, C. Kan, Desiree Ehleiter et al. · The Journal of Experimental Medicine · 1994 · 902 citations · Full text

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Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

Ron Bose, Marcel Verheij, Adriana Haimovitz‐Friedman et al. · Cell · 1995 · 836 citations · Full text

, , +15

DNA damage induces phosphorylation of the amino terminus of p53

Janet D. Siliciano, Christine E. Canman, Yoichi Taya et al. · Genes & Development · 1997 · 825 citations · Full text

, , +17

Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.

M Y Kim, C.M. Linardic, Lina M. Obeid et al. · Journal of Biological Chemistry · 1991 · 631 citations · Full text

, , +11

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

Maria Grazia Cifone, Ruggero De Maria, Paola Roncaioli et al. · The Journal of Experimental Medicine · 1994 · 579 citations · Full text

, , +17