The Small-Molecule Inhibitor BI 2536 Reveals Novel Insights into Mitotic Roles of Polo-like Kinase 1

Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen

Thomas U. Mayer, Tarun M. Kapoor, Stephen J. Haggarty et al. · Science · 1999 · 1.7K citations

Molecular Biology, Small Molecule Inhibitor, Cytoskeleton +18

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

Claire Ditchfield, Victoria Johnson, Anthony Tighe et al. · The Journal of Cell Biology · 2003 · 1.2K citations · Full text

Genetics, Molecular Biology, Aurora B +16

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint

Silke Hauf, Richard W. Cole, Sabrina LaTerra et al. · The Journal of Cell Biology · 2003 · 1.2K citations · Full text

VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

Elizabeth A. Harrington, David Bebbington, Jeffrey R. Moore et al. · Nature Medicine · 2004 · 948 citations · Full text

Selective Small-molecule Inhibitor, Signal Transduction, Signaling Pathway +11

BI 2536, a Potent and Selective Inhibitor of Polo-like Kinase 1, Inhibits Tumor Growth In Vivo

Martin Steegmaier, Matthias Hoffmann, Anke Baum et al. · Current Biology · 2007 · 839 citations · Full text

Tumor Biology, Bi 2536, Medicine +9