Morphobase, an Encyclopedic Cell Morphology Database, and Its Use for Drug Target Identification

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

Gabriel Fenteany, Robert F. Standaert, William S. Lane et al. · Science · 1995 · 1.6K citations

Lactacystin Analogs, Lmp7 Proteasome Subunit, Protein Function +12

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

Luke Whitesell, Edward G. Mimnaugh, B. de Costa et al. · Proceedings of the National Academy of Sciences · 1994 · 1.4K citations · Full text

Molecular Regulation, Molecular Biology, Hsp Participation +17

Multidimensional Drug Profiling By Automated Microscopy

Zachary E. Perlman, Michael D. Slack, Feng Yan et al. · Science · 2004 · 668 citations

Drug Target, Engineering, Quantitative Pharmacology +19

Induction of terminal differentiation in human promyelocytic leukemia cells by tumor-promoting agents.

Eliezer Huberman, Michael F. Callaham · Proceedings of the National Academy of Sciences · 1979 · 504 citations · Full text

Hematological Malignancy, Terminal Differentiation, Medicine +15

Identifying off-target effects and hidden phenotypes of drugs in human cells

Marnie L. MacDonald, Jane E. Lamerdin, Stephen Owens et al. · Nature Chemical Biology · 2006 · 296 citations

Drug Target, Hidden Phenotypes, Human Cells +8