Concepedia

A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth

Lei Wang, Jianjun Chang, Diana Varghese, Michael T. Dellinger, Subodh Kumar, Anne M. Best, Julio C. Ruiz, Richard K. Bruick, Samuel Peña‐Llopis, Junjie Xu,

Nature Communications · 2013 · 324 citations · 43 references

DOIFull text

Open access

Concepts

References

43

The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease

Justin Lamb, Emily Crawford, D. D. Peck et al. · Science · 2006 · 5.5K citations

, , +16

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

Sreenath V. Sharma, Diana Lee, Bihua Li et al. · Cell · 2010 · 2.8K citations · Full text

, , +14

Reversal of Histone Lysine Trimethylation by the JMJD2 Family of Histone Demethylases

Johnathan R. Whetstine, Amanda C. Nottke, Fei Lan et al. · Cell · 2006 · 1K citations · Full text

, , +12

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

Laurens Kruidenier, Chun‐wa Chung, Zhongjun Cheng et al. · Nature · 2012 · 958 citations · Full text

, , +14

The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3

Paul A. Cloos, Karl Agger, Alessio Maiolica et al. · Nature · 2006 · 749 citations

, , +15