Inhibition of avian myeloblastosis virus reverse transcriptase by diphosphates of acyclic phosphonylmethyl nucleotide analogues

A novel selective broad-spectrum anti-DNA virus agent

Erik De Clercq, Ivan Rosenberg, Takashi Sakuma et al. · Nature · 1986 · 764 citations

Pharmacy, Medicinal Chemistry, Microbiology +9

Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines

Erik De Clercq, Takashi Sakuma, Masanori Baba et al. · Antiviral Research · 1987 · 513 citations

Medicine, Medicinal Chemistry, Pharmacology +14

Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents

Rudi Pauwels, Jan Balzarini, Dominique Schols et al. · Antimicrobial Agents and Chemotherapy · 1988 · 256 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent.

Jan Balzarini, Lieve Naesens, Piet Herdewijn et al. · Proceedings of the National Academy of Sciences · 1989 · 218 citations · Full text

Medicine, Oncology, Pharmacology +11

9-(2-phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys

Jan Balzarini, Lieve Naesens, J. F. A. M. Slachmuylders et al. · AIDS · 1991 · 214 citations

Life Sciences, Infectious Diseases, Pharmacotherapy +17