Heterocyclic aromatic amines in human urine following a fried meat meal

CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is their major route of metabolism in humans.

Alan R. Boobis, Anthony M. Lynch, Sandra Murray et al. · PubMed · 1994 · 261 citations

Medicine, Pharmacokinetics, Pharmacology +15

Effect of cooking time and temperature on the heterocyclic amine content of fried beef patties

Mark G. Knize, Frank Dolbeare, K. L. Carroll et al. · Food and Chemical Toxicology · 1994 · 225 citations

Agriculture, Food Science, Food Analysis +13

Presence of carcinogenic heterocyclic amines in urine of healthy volunteers eating normal diet, but not of inpatients receiving parenteral alimentation

Hirofumi USHIYAMA, Keiji Wakabayashi, M Hirose et al. · Carcinogenesis · 1991 · 184 citations

Pharmacy, Nutrition, Toxicology +10

Detection of a carcinogen, 2-amino-1-methyl-6-phenylimidazo [4,5-<i>b</i>]pyridine (PhIP), in cigarette smoke condensate

Shigeo Manabe, Kazuhiko Tohyama, Osamu Wada et al. · Carcinogenesis · 1991 · 175 citations

Pharmacy, Toxicology, Analytical Toxicology +4

Contribution of CYP1A1 and CYP1A2 to the activation of heterocyclic amines in monkeys and human

Robert J. Edwards, Bernard P. Murray, Stephen A. Murray et al. · Carcinogenesis · 1994 · 125 citations

Medicine, Pharmacology, Toxicology +17